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深圳大学医学部朱卫国教授团队揭示组蛋白修饰参与DNA复制的新机制

来源: 发布时间:2020-06-10 11:11 点击数: Views

DNAFUZHISHIYIGESHIFENJINGXIDEFENZIDIAOKONGGUOCHENG, ZAIDNAFUZHIGUOCHENGZHONGTINEITIWAIDALIANGDECIJIYINSURUUV、RANSEZHIGAOJIJIEGOUDEZULANDENGHUICHANSHENGDNAFUZHIYALI(replication stress),CONGERSHIDEFUZHICHATINGZHI(fork stall)SHENZHIKUATA(fork collapse)ZAOCHENGDNASUNSHANG(DNA damage),JINERDAOZHIJIYINZUBUWENDING,YINCIDNAFUZHIYINGJIDEXIANGYINGHEXIUFUDUIYUBAOZHENGDNAFUZHIWANCHENGDEZHUNQUEXINGHERANSEZHIWENDINGXINGYIJIZHENGCHANGDEXIBAOMINGYUNJUYOUZHONGYAOYIYI。

2021NIAN6YUE2RI,SHENZHENDAXUEZHUWEIGUOJIAOSHOUTUANDUIZAI《MEIGUOKEXUEYUANYUANBAO》(PNAS)ZAIXIANFABIAOTIWEISETD2-mediated H3K14 trimethylation promotes ATR activation and stalled replication fork restart in response to DNA replication stressDEZHANGWENWENZHANG,JIESHILEZUDANBAIJIAJIHUAXIUSHICANYUDIAOKONGATRXINHAOTONGLUJIHUO,BINGCUJINTINGZHIDEDNAFUZHICHAZHONGQIDEZHONGYAOGONGNENG。 GAIXIANGYANJIUJIANDINGLEXINDEZUDANBAIJIAJIHUAXIUSHIWEIDIANH3K14me3DEJIAJIHUAMEI,FAXIANZUDANBAIXIUSHINENGGOUZHIJIEYINGXIANGRPAFUHEWUZAIRANSEZHISHANGDEZHAOMU,CONGERJIANGZUDANBAIXIUSHIYUATRXINHAOTONGLUDEJIHUOLIANXIQILAI,SHUOMINGZUDANBAIXIUSHICANYUDIAOKONGLEDNAFUZHIYALIDEZUIKAISHIDEXIANGYINGGUOCHENG。SHENZHENDAXUEZHUWEIGUOJIAOSHOUHELIUXIANGYUYANJIUYUANWEIBENWENDETONGXUNZUOZHE,SHENZHENDAXUEBOSHIHOUZHUQIANWEIBENWENDEDIYIZUOZHE。

DNAFUZHIYALITIAOJIANXIASETD2JIEDAODEH3K14me3DIAOKONGATRJIHUODEXINHAOTONGLU

YUANWENLIANJIE:

(YIXUEBU  GONGGAO)

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